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Our results illustrate that pregnancy-induced brain changes are detectable even at six years after parturition; at this period, the brain of a mother is still different from that of a nulliparous woman. In fact, based exclusively on Grey Matter volume changes, we can correctly classify women as having undergone pregnancy or not with 91.67% of total accuracy. These findings open the possibility that the brain changes induced by pregnancy are lifelong and enduring.
——Martínez-García M, Paternina-Die M, Barba-Müller E, et al. Do pregnancy-induced brain changes reverse? The brain of a mother six years after parturition. Brain sciences, 2021, 11(2): 168.
To date, the only two well-controlled longitudinal studies encompassing the whole pregnancy period compared the brains of first-time mothers between pre-conception and 2–3 months postpartum. We collected neuroanatomic, obstetric and neuropsychological data from 110 first-time mothers during late pregnancy and early postpartum, as well as from 34 nulliparous women evaluated at similar time points. During late pregnancy, mothers showed lower cortical volume than controls across all functional networks. These cortical differences attenuated in the early postpartum session. Default mode and frontoparietal networks showed below-expected volume increases during peripartum, suggesting that their reductions may persist longer. It is important to note that literature on the maternal brain largely relies on Western samples of highly educated mothers with a medium–high socio-economic status.
——Paternina-Die M, Martínez-García M, Martín de Blas D, et al. Women’s neuroplasticity during gestation, childbirth and postpartum. Nature Neuroscience, 2024, 27(2): 319-327.
We applied a meta-analytic quantitative approach to investigating the association between pregnancy and changes in cognitive functioning, and reached two major conclusions. First, the general cognitive functioning, memory, and executive functioning performance of pregnant women is significantly lower than in non-pregnant women, both overall and particularly during the third trimester. Secondly, the memory performance of pregnant women appears to decline between the first and second trimesters.
——Davies S J, Lum J A G, Skouteris H, et al. Cognitive impairment during pregnancy: a meta‐analysis. Medical Journal of Australia, 2018, 208(1): 35-40.
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