Advances in Experimental Medicine and Biology 丛书（请勿跟帖，谢谢！！！）

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Chemistry and Safety of Acrylamide in Food
(Advances in Experimental Medicine and Biology)

By Mendel Friedman, Don Mottram

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Publisher:  Springer
Number Of Pages:  466
Publication Date:  2005-04-22
ISBN-10 / ASIN:  0387239200
ISBN-13 / EAN:  9780387239200
Binding:  Hardcover

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Book Description:
Reports that heat processing of foods induces the formation of acrylamide heightened interest in the chemistry, biochemistry, and safety of this compound. Acrylamide-induced neurotoxicity, reproductive toxicity, genotoxicity, and carcinogenicity are potential human health risks based on animal studies. Because exposure of humans to acrylamide can come from both external sources and the diet, there exists a need to develop a better understanding of its formation and distribution in food and its role in human health. To contribute to this effort, experts from eight countries have presented data on the chemistry, analysis, metabolism, pharmacology, and toxicology of acrylamide. Specifically covered are the following aspects: exposure from the environment and the diet; biomarkers of exposure; risk assessment; epidemiology; mechanism of formation in food; biological alkylation of amino acids, peptides, proteins, and DNA by acrylamide and its epoxide metabolite glycidamide; neurotoxicity, reproductive toxicity, and carcinogenicity; protection against adverse effects; and possible approaches to reducing levels in food. Cross-fertilization of ideas among several disciplines in which an interest in acrylamide has developed, including food science, pharmacology, toxicology, and medicine, will provide a better understanding of the chemistry and biology of acrylamide in food, and can lead to the development of food processes to decrease the acrylamide content of the diet.

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file:///C:/Documents%20and%20Settings/Brian%20Lee/My%20Documents/My%20Pictures/0.jpgTNF Receptor Associated Factors
(Advances in Experimental Medicine and Biology)

By Hao Wu

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Publisher: Springer
Number Of Pages: 225
Publication Date: 2007-06-25
ISBN-10 / ASIN: 0387706291
ISBN-13 / EAN: 9780387706290
Binding: Hardcover

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Product Description:


It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer.
TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.

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Drug Targets in Kinetoplastid Parasites
(Advances in Experimental Medicine and Biology)

By Hemanta K. Majumder

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Publisher:  Springer
Number Of Pages:  178
Publication Date:  2008-01-23
ISBN-10 / ASIN:  0387775692
ISBN-13 / EAN:  9780387775692
Binding:  Hardcover

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Product Description:

If viewed globally, the parasitic diseases pose an increasing threat to human health and welfare. The diseases caused by kinetoplastid protozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas disease is endemic in Latin America, while members of Trypanosoma brucei group are found in sub-Saharan Africa. Although the past two decades has witnessed commendable research efforts and technical advances in our understanding of the biochemistry, molecular and cell biology of these pathogens, the dreaded protozoal diseases caused by these organisms threaten mankind. Therapeutic tools for the treatment of most parasitic diseases are extremely limited. The development of parasites resistant to many of the available drugs is also responsible for the depressing picture of disease persistence and death. Development of commercially available vaccines is still far from reality, though research and trial programs continue.

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Oxygen Transport to Tissue XXVIII
(Advances in Experimental Medicine and Biology)

By David Maguire, Duane F. Bruley, David K. Harrison

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Publisher: Springer
Number Of Pages: 226
Publication Date: 2007-08-07
ISBN-10 / ASIN: 0387717633
ISBN-13 / EAN: 9780387717630
Binding: Hardcover

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Product Description:


This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism as discussed at the 33rd Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) will be held in Brisbane, Queensland, Australia, August 2005. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.

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Osteoimmunology: Interactions of the Immune and Skeletal Systems
(Advances in Experimental Medicine and Biology)

By Yongwon Choi

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Publisher: Springer
Number Of Pages: 156
Publication Date: 2007-10-01
ISBN-10 / ASIN: 0387720081
ISBN-13 / EAN: 9780387720081
Binding: Hardcover

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Product Description:


A Key Regulator of Postnatal Skeletal Remodeling.- Ectodomain Shedding of Receptor Activator of NF-KB Ligand.- The Negative Role Of Ids In Osteoclastogenesis.- Functional Genetic and Genomic Analysis of Modeled Arthritis.- Dexamethsone Suppresses Bone Formation via the Osteoclast.- Immunologic Regulation Of Bone Development.- Pth Regulates The Hematopoietic Stem Cell Niche In Bone.- Regulation Of Hematopoietic Stem Cells In The Osteoblastic Niche.- The Chemokine Cxcl12 And Regulation Of Hsc And Lymphocyte Development In The Bone Marrow Niche.- Osteoclast Precursor Cells.- Interaction with estrogen receptors as treatment of arthritis and osteoporosis.- Novel Signaling Pathways And Therapeutic Targets In Osteoclasts.- The Enigmatic Function of TREM-2 in Osteoclastogenesis.- Role of cell-matrix interactions in osteoclast differentiation.- Positive and negative roles of IL-6, STAT3 and SOCS3 in inflammatory arthritis.- Control of Osteoclast activity and bone loss by IKK subunits: new targets for therapy.- Targeting Osteoporosis And Rheumatoid Arthritis By Active Vaccination Against Rankl.- RANKL Inhibition: From Mice to Men (and Women).

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Targeted Therapies in Cancer: Myth or Reality?
(Advances in Experimental Medicine and Biology)

By Francesco Colotta, Alberto Mantovani

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Publisher: Springer
Number Of Pages: 192
Publication Date: 2007-12-10
ISBN-10 / ASIN: 0387738975
ISBN-13 / EAN: 9780387738970
Binding: Hardcover

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Product Description:


In September 2005 an International Meeting on Targeted Therapies in Cancer: Myth or Reality was held in Milan. This successful Meeting was intended to represent a forum for scientists and clinicians working in cancer drug discovery and therapy to share their reflections and experiences on how the paradigm shift from empiricism to molecular targeted therapies is contributing to the translation of basic knowledge into new therapies for cancer patients. This book collects the contributions given by scientists and clinicians, from Academia and Industry, who participated to this Meeting.
We hope that this book contributes to improve our approach to cancer drug discovery and, ultimately, to find new, more efficacious and better tolerated drugs for cancer patients. It provides an overview of diverse approaches ranging from drug discovery to cellular therapy. Although this change in paradigm has been useful, its entry into the clinical arena was associates with unforeseen problems including the emergence of resistance, unexpected side effects and failures. Time is therefore ripe for a critical cultural reflection on the state of the art, prospects and limitations. Ultimately, is targeted therapy in cancer a myth or a reality?

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Eukaryotic Membranes and Cytoskeleton: Origins and Evolution
(Advances in Experimental Medicine and Biology)

By G谩sp谩r J茅kely

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Publisher: Springer
Number Of Pages: 162
Publication Date: 2007-09-14
ISBN-10 / ASIN: 0387740201
ISBN-13 / EAN: 9780387740201
Binding: Hardcover

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Product Description:

Eukaryotic Membranes and Cytoskeleton: Origins and Evolution discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective. Many of the chapters present original research data from comparative genomic surveys. The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow us to accurately reconstruct the cellular machineries present in the last common ancestor of eukaryotes. Such a reconstruction is fundamental if we are to understand eukaryotic diversification since this is the ancestral cell from which all diversity arose. Comparative genomics can likewise tell us which lineages expanded or reduced certain gene families and the associated cellular machineries.

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The Biology and Pathology of Innate Immunity Mechanisms
(ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY)
By Yona Keisari, Itzhak Ofek

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Publisher:  Springer
Number Of Pages:  338
Publication Date:  2000-06-30
ISBN-10 / ASIN:  0306464098
ISBN-13 / EAN:  9780306464096
Binding:  Hardcover

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Product Description:
This book is the proceedings of the Bathsheva de Rothschild Seminar on Innate Immunity, held on October 10-15, 1999, in Zichron Yaakov, Israel.
In recent years, scientific attention has focused increasingly on immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body's defense. Identification of pathogens by these mechanisms primarily involves receptors recognizing sugar moieties of various microorganisms. This major new volume describes the recent discoveries in this field, including the implications of the recognition of specific components of the innate immunity arsenal as the main cause of host susceptibility to particular types of infections, and the development of new agents to combat infections using newly identified anti-microbial peptides. There is also coverage of the major themes, such as (i) the role of innate immune responses as a first-line defense against microbial infection and tumor cells; (ii) the cellular and molecular basis of the function of cells and molecules involved in innate immunity; (iii) the role of innate immunity in the immunocompromised host; and (iv) the interactions between innate immunity components and clonal immune response.

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Current Views of Fatty Acid Oxidation and Ketogenesis - From Organelles to Point Mutations
(Advances in Experimental Medicine and Biology)

By Patti A. Quant, Simon Eaton

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Publisher: Springer
Number Of Pages: 460
Publication Date: 1999-10-01
ISBN-10 / ASIN: 0306462001
ISBN-13 / EAN: 9780306462009
Binding: Hardcover

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Book Description:

This book brings together biochemical, genetic, molecular biology, and clinical approaches to the study of fatty acid oxidation. Including current research from most of the major groups working in this field, it provides a multi-disciplinary approach to the subject and an up-to-date overview of the most recent developments and debates.

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Ovarian Cancer: State of the Art and Future Directions in Translational Research
(Advances in Experimental Medicine and Biology)

By George Coukos, Andrew Berchuck, Robert Ozols

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Publisher: Springer
Number Of Pages: 302
Publication Date: 2008-05-09
ISBN-10 / ASIN: 0387689664
ISBN-13 / EAN: 9780387689661
Binding: Hardcover

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Product Description:

Aegean Conferences is an independent, nonprofit, educational organization directed and managed by the scientific community. The board is made up of nine researchers/scientists in various disciplines from Harvard, Brown, University of Pennsylvania, UCSD, Princeton, Biovista and the Foundation for Biomedical Research Academy of Athens. The board both invites and approves unsolicited proposals for Conferences in all fields of Science, Engineering, Arts, and Humanities. The purpose of the Conferences is to bring together individuals with common interests to examine the emerging and most advanced aspects of their particular field.
The Symposium on Ovarian Cancer: State of the Art and Future Directions intends to bring together international experts interested in the development of novel diagnostic, prognostic and therapeutic tools for ovarian cancer. The meeting will function as a think tank where clinicians, translational and basic scientists, and parties from the biotechnology and pharmaceutical industry will get together to review recent advances in clinical research and translational science in ovarian cancer and define areas of future research opportunities and priorities.

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TNF Receptor Associated Factors
(Advances in Experimental Medicine and Biology)
By Hao Wu

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Publisher: Springer
Number Of Pages: 225
Publication Date: 2007-06-25
ISBN-10 / ASIN: 0387706291
ISBN-13 / EAN: 9780387706290
Binding: Hardcover

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Product Description:

It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer.
TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.

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The Genus Yersinia: From Genomics to Function
(Advances in Experimental Medicine and Biology)

By Robert D. Perry, Jacqueline D. Fetherston

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Publisher:  Springer
Number Of Pages:  432
Publication Date:  2007-09-25
ISBN-10 / ASIN:  0387721231
ISBN-13 / EAN:  9780387721231
Binding:  Hardcover

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Product Description:

The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field.

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Genes and Proteins Underlying Microbial Urinary Tract Virulence - Basic Aspects and Applications

(Advances in Experimental Medicine and Biology)

By Levente Emody, Tibor Pál, Gabriele Blum-Oehler, J鰎g H. Hacker

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Publisher: Springer
Number Of Pages: 382
Publication Date: 2000-10
ISBN-10 / ASIN: 0306464551
ISBN-13 / EAN: 9780306464553
Binding: Hardcover

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Book Description:

Proceedings of the FEMS Symposium on Genes and Proteins Underlying Microbial Urinary Tract Virulence: Basic Aspects and Applications, held September 16-19, 1999, in Pécs, Hungary.
Urinary tract infections are among the most frequent diseases caused by microbial pathogens. In this volume, researchers, clinical microbiologists and clinicians exchange the latest ideas covering four major aspects of this important topic:

[li]Genetic information, synthesis and assembly of virulence factors in urinary pathogens; [/li][li]Regulation of genes involved in the phenotypic appearance of virulence; [/li][li]Host-parasite interactions determining the process and outcome of the infection; [/li][li]Possible applications of the above aspects in diagnosis, therapy and prevention. [/li]

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Neuropilin: From Nervous System to Vascular and Tumor Biology
(Advances in Experimental Medicine and Biology)
By Dominique Bagnard

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Publisher: Springer
Number Of Pages: 140
Publication Date: 2003-01-31
ISBN-10 / ASIN: 0306474166
ISBN-13 / EAN: 9780306474163
Binding: Hardcover

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Product Description:

This volume provides an analysis on how a single molecule is able to encode a wide range of functions in various biological systems, contributing to the disappearance of frontiers in biology. Beneficial for scientists of multiple fields, interested by the consequence of sophisticated mechanisms of signal transduction, this volume is a general model for the understanding of a multifunctional factor, a model that may apply for a variety of signals during both physiological and pathological cellular behavior.

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Dipeptidyl Aminopeptidases in Health and Disease
(Advances in Experimental Medicine and Biology)
By Martin Hildebrandt, Burghard Klapp, Torsten Hoffmann, Hans-Ulrich Demuth

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Publisher:  Springer
Number Of Pages:  396
Publication Date:  2003-03-31
ISBN-10 / ASIN:  0306477173
ISBN-13 / EAN:  9780306477171
Binding:  Hardcover

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Product Description:


Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany.
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes.
Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics:

- Structure and function of dipeptidyl aminopeptidases,
- DPP IV-like proteins,
- Immune mechanisms and immune disorders,
- Cancer and angiogenesis,
- Diabetes and metabolism,
- Therapeutic implications.

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