胰岛素缺陷预示着老年痴呆？

hxq2007

Insulin Trouble Tied to Alzheimer's
胰岛素缺陷预示着老年痴呆？

Study: Diabetes and Other Insulin Issues at Age 50 May Predict Alzheimer's Disease Decades Later
研究： 在50岁时患糖尿病和其他胰岛素有关的问题可能预示10年后得Alzheimer病
People with diabetes or other insulin problems at age 50 may be especially likely to develop Alzheimer's disease decades later.
人们在50岁时患糖尿病或其他胰岛素相关的问题可能预示10年后发展为Alzheimer病

That news comes from a Swedish study of more than 2,200 men followed for up to 35 years, starting at age 50.
消息来自于瑞典的一个研究，共超过2200名男性，并且随访超过35年的。

\"Our results suggest a link between insulin problems and the origins of Alzheimer's disease and emphasize the importance of insulin in normal brain function,\" Elina Ronnemaa, MD, of Sweden's Uppsala University, says in a news release. \"It's possible that insulin problems damage blood vessels in the brain, which leads to memory problems and Alzheimer's disease, but more research is needed to identify the exact mechanisms.\"
瑞典Uppsala 大学Elina Ronnemaa医生在一个新闻透露会上说：“我们的结果提示了胰岛素问题与Alzheimer病起源之间的联系，强调胰岛素对正常脑功能的重要性。胰岛素的问题可能损伤脑部血管，导致记忆障碍和Alzheimer病，但需要更多的研究来阐明其机制。”

When the Swedish study started, the men took fasting glucose tests to show how well their body used insulin, a hormone that controls blood sugar.
在这个瑞典的研究开始过程时，人们用快速血糖试验来检测机体利用胰岛素的程度，胰岛素是调节血糖的一种激素。

Men who had a weaker insulin response to that test were 31% more likely to be diagnosed with Alzheimer's disease later in life, regardless of other factors such as age, BMI (body mass index), and education level.
在胰岛素反应较弱男性中有31%可能性在以后诊断为Alzheimer病，而与其他因素如年龄，身体质量指数（BMI-Body Mass Index），和教育程度无关。

That pattern applied to men with and without diabetes; it was strongest among men without the Alzheimer's-related APOE4 gene variation.
如果把上述结果应用到有和无糖尿病的男性中；发现在没有Alzheimer相关的APOE4基因变异组中提示最强。

The findings, published in today's online edition of Neurology, follow a study released in 2007 linking poorly controlled diabetes to Alzheimer's disease and other research on the link between diabetes and Alzheimer's disease.
从2007年发现糖尿病控制不良与Alzheimer病有关，和其他研究发现糖尿病与Alzheimer病的关系后，跟随着的这次新的结果，在今天的《神经学》 Neurology网络版发表。

However, there are other risk factors for Alzheimer's disease, and as the Swedish researchers point out, it will take more work to put together all the pieces of the puzzle.
然而，瑞典的研究者指出，Alzheimer病还存在着其他危险因素，需要做更多的工作综合起来分析这个难题。”