红酒中抗氧化剂能抗癌

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Red Wine Antioxidant Fights Cancer

Resveratrol and Radiation Team Up to Destroy Pancreatic Cancer Cells

March 26, 2008 -- A new study shows an antioxidant found in red wine destroys cancer cells from the inside and enhances the effectiveness of radiation and chemotherapy cancer treatments.

Researchers say the antioxidant found in grape skins, known as resveratrol, appears to work by targeting the cancer cell's energy source from within and crippling it. When combined with radiation, treatment with resveratrol prior to radiation also induced cell death, an important goal of cancer treatment.

The researchers note that although resveratrol might reduce pancreatic cancer's resistance to chemotherapy, \"the impact of red wine consumption on chemotherapy remains unclear.\"

Researcher Paul Okunieff, MD, chief of radiation oncology at the University of Rochester Medical Center, says red wine consumption during chemotherapy or radiation treatment has not been well studied, but it's not prohibited. Okunieff says if a cancer patient already drinks red wine moderately, most physicians wouldn't tell the patient to give it up. But perhaps a better choice might be to drink as much red or purple grape juice, which also contains resveratrol, as desired.

\"Antioxidant research is very active and very seductive right now,\" Okunieff says in a news release. \"The challenge lies in finding the right concentration and how it works inside the cell. In this case, we've discovered an important part of that equation. Resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making normal tissue less sensitive.\"

Resveratrol Targets Cancer Cells

In the study, published in Advances in Experimental Medicine and Biology, researchers examined the effects of a 50 microgram/milliliter dose of resveratrol on pancreatic cancer cells alone and in combination with radiation treatment. By comparison, the resveratrol concentration in red wine can be as high as 30 micrograms/milliliter.

The results showed that resveratrol had a variety of potentially valuable anti-cancer effects, including:

1、Making the cancer cells more sensitive to chemotherapy by hampering proteins that resist treatment

2、Triggering cancer cell death (apoptosis)

3、Injuring the cancer cell's energy source and decreasing its potential to function

\"While additional studies are needed, this research indicates that resveratrol has a promising future as part of the treatment for cancer,\" Okunieff says.
红酒中抗氧化剂能抗癌
白藜芦醇和辐射协同破坏胰腺癌细胞

2008年三月26 –最新研究显示，一种红酒中发现的抗氧化剂从内部破坏癌细胞并增强癌症放化疗的疗效。

研究者说，该被称为白藜芦醇的抗氧化剂存在于葡萄皮中，显示出能靶向作用于癌细胞的能量代谢，从内部作用并削弱之。当其与辐射联合（白藜芦醇先于辐射）也诱导细胞死亡（癌症治疗的一个重要的目标）。

研究者注意到，尽管白藜芦醇可能减低胰腺癌的化疗抗药性，“饮用红酒对化疗的影响仍未清除。”

Rochester大学医学中心首席放射肿瘤学家，研究员Paul Okunieff博士说，在化疗或放疗期间饮用红酒尚未很好的研究，但却不是禁止的。Okunieff说，如果一个癌症病人已经饮用适量红酒，多数医师将不会让该病人戒酒。但或许更好的选择是，饮用尽自己所需的红或紫葡萄汁，后者一样含有白藜芦醇。

“抗氧化剂研究目前是非常活跃、非常诱人的，”Okunieff在新闻稿中说。“挑战在于发现正确的药物浓度，和在细胞内部如何起作用。该研究中，我们已经发现该通路的一个重要部分。白藜芦醇似乎通过使癌细胞对辐射更敏感并使正常组织更不敏感而具有治疗效益。”

白藜芦醇靶向癌细胞

本研究即将发表在《医学与生物学实验》，研究者检测了剂量50 mg/ml白藜芦醇联合辐射处理对胰腺癌细胞系的影响。通过对照，红酒中白藜芦醇浓度可高达30mg/ml。

结果显示，白藜芦醇具有多种有价值的抗癌效应潜能，包括：

1、通过阻止抗药性蛋白使癌细胞对化疗更敏感

2、触发癌细胞死亡(凋亡)

3、损伤癌细胞的能量代谢并减少其潜在功能

“虽然尚需要深入研究，该研究表明，白藜芦醇在癌症治疗中非常有前途，”Okunieff说。


国内有一些白藜芦醇相关的保健品,
白藜芦醇属于植物多酚类物质，其对包括胰腺癌等多种实体肿瘤的治疗作用已经早有报道，本文属于效仿其他植物多酚类在放射治疗领域的研究报道，所以仅发表在影响因子（2006）为0.646的 《Advances in Experimental Medicine and Biology》杂志上，之前的同类文章可发在影响因子7.0以上的杂志。