血尿酸增高，患糖尿病的危险增加

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Risk of Developing Diabetes Increases With Rising Serum Uric Acid Levels
NEW YORK (Reuters Health) Feb 26 - Serum uric acid is a strong and independent risk factor for diabetes, according to findings published in the February issue of Diabetes Care.
路透社2008年2月26日纽约讯------根据《糖尿病护理》杂志二月刊上一项研究报告的结果,尿酸是糖尿病强烈且独立的危险因素。
\"Serum uric acid is positively associated with serum glucose in healthy subjects,\" Dr. Jacqueline C. M. Witteman and colleagues from Erasmus Medical Center, Rotterdam, the Netherlands, write. \"However, this association is not consistent between healthy and diabetic individuals, as a low serum level of uric acid is reported in the hyperglycemic state,\" they note. \"Since most individuals experience a phase of impaired glucose tolerance before progression to diabetes, it is not clear whether raised serum uric acid predicts the risk of type 2 diabetes.\"
来自荷兰鹿特丹市伊拉兹马斯医学中心的Jacqueline C. M. Witteman博士和同事：“对于正常人，血清尿酸与血清葡萄糖呈正相关。然而，这种关联在健康人与糖尿病患者身上并没有完全依从性，报道有处于高血糖状态但血尿酸非常低的人。由于多数人在进展到糖尿病之前经历糖耐量低减这个阶段，目前尚不清楚血清尿酸增高是否能预测具有患二型糖尿病的危险。
To investigate, the researchers used data from the Rotterdam Study, a large population-based, prospective cohort study among subjects aged 55 years and older. Included in the study were 4536 subjects free from diabetes at baseline.
调查中，研究人员所用的数据来自鹿特丹的研究，是大群体的前瞻性队列研究，4536名受试者年龄在55岁以上，均没有糖尿病。
The mean serum uric acid level measured at baseline was 323.7 micromol/L (range, 107 to 756 micromol/L). Among the participants, 462 developed diabetes during a mean follow-up of 10.1 years.
测定的平均血清尿酸水平为323.7 micromol /L（正常范围：107至756 micromol /L）。对受试者随访了平均10.1年，有462人发展成为糖尿病。
The age- and sex-adjusted hazard ratios for diabetes were 1.30, 1.63, and 2.83 for the second, third, and fourth quartiles of serum uric acid, in comparison with the first quartile. On multivariate analysis, the corresponding hazard ratios dropped to 1.08, 1.12, and 1.68, the researchers report.
研究人员报道：在年龄和性别做了相应调整后与第一次血清尿酸四分位数相比较，第二次糖尿病的危害比为1.30，第三次为1.63，第四次为2.83,。据多变量分析后，相应的危险比降至1.08,1.12,1.68。
\"Our findings, together with those from previous literature, indicate that lowering uric acid may be a novel treatment target for preventing diabetes and justify a prospective clinical trial on the possible benefits of the measurement and lowering of serum uric acid on multiple chronic disease end points,\" Dr. Witteman and colleagues conclude.
Witteman 博士和他的同事总结：“我们的研究和之前的文献均表明，降低血尿酸对于预防和延缓糖尿病是一新的治疗方案。调整前瞻性研究，使测量数据更有价值。对多发性慢性疾病有终点事件的患者降低血尿酸还是有意义的。”（Diabetes Care 2008;31:361-362.）