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Total and HDL cholesterol levels unrelated to heart failure
MedWire News: Total and high-density lipoprotein (HDL) cholesterol levels are not associated with the risk for heart failure, but are related to coronary heart disease (CHD) risk, show results from the Physicians' Health Study in the USA.
MedWire新闻：美国医师健康研究结果显示，总胆固醇和高密度脂蛋白（HDL）胆固醇水平和心衰风险没有关联，但是和冠心病（CHD）风险相关。
High levels of total cholesterol and low levels of HDL cholesterol are well recognized as risk factors for CHD, but their link to heart failure is less clear and previous studies have produced conflicting evidence.
高水平的总胆固醇和低水平的HDL胆固醇是CHD的风险因素已经被人们很好的认识到了，可是它们和心衰的关系尚不清楚，之前的研究得出的证据并不一致。
Ravi Dhingra (Alice Peck Day Memorial Hospital, Lebanon, New Hampshire, USA) and colleagues investigated the potential association between heart failure and levels of total and HDL cholesterol in 10,813 men, with an average age of 68 years, recruited from the US Physicians' Health Study.
Ravi Dhingra（美国新罕布什尔州，黎巴嫩，Alice Peck Day纪念医院）和同事研究了心衰和总胆固醇和HDL胆固醇水平的潜在关系，总共有10,813名男性，平均年龄68岁，补充了美国医师健康的研究。
Over a follow-up period of approximately 6 years, 222 incident heart failure cases were recorded in the study population. Increases in total cholesterol of 36.7 mg/dl (0.95 mmol/l) and in HDL cholesterol of 15.3 mg/dl (0.40 mmol/l) were both associated with a 15% decrease in the risk for heart failure. However, these associations were abolished after accounting for standard risk factors for CHD such as body mass index.
在接近6年的随访期里，研究人群中有222人发生了心衰事件，总胆固醇36.7 mg/dl (0.95 mmol/l)和HDL胆固醇15.3 mg/dl (0.40 mmol/l)的增高和心衰风险下降15%都被关联在一起。然而，在解释CHD的保准风险因素（像体重指数）后，这种关联就被废除了。
There was also no statistically significant link between risk for heart failure and the ratio of total to HDL cholesterol. However, as expected high total cholesterol and low HDL cholesterol levels were associated with increased risk for CHD in the study population. Individuals in the highest quartile for total and HDL cholesterol had a 40% higher and 47% lower risk for CHD when compared with those in the lowest quartile, respectively. The results are reported in the American Heart Journal.
心衰风险和总胆固醇和HDL胆固醇比率之间的关联并没有统计学意义。然而，在研究人群中，高总胆固醇和低HDL水平被认为和增加CHD风险是联系在一起的。分别比较最高的和最低的四位数个体，总胆固醇和HDL胆固醇高40%，CHD风险低47%。这一结果报导在《美国心脏杂志》上。
Some previous studies have linked an elevated total/HDL cholesterol ratio and raised triglycerides to onset of heart failure, but the authors point out that \"most other studies did not find any association.\" They remark that, unlike similar previous studies, the current study was not limited by sample size.
早先的一些研究将升高的总胆固醇和HDL胆固醇比率和增高的甘油三酯和心衰的其实联系到一起，但是作者指出“绝大多数其他研究都内有发现任何关系。”他们评论，和先前的研究不同，目前的研究没有样本量大小的限制。
Dhingra and colleagues conclude: \"In our large healthy sample of males free of heart failure, total cholesterol and HDL cholesterol were not associated with incidence of heart failure.\" They add: \"If confirmed, additional research studies are required to explore other techniques besides lowering cholesterol in primary prevention of heart failure.\"
Dhingra和同事得出结论：“在我们健康的，男性无心衰的大样本里，总胆固醇和HDL胆固醇和心衰的发生没有关系.”他们补充到，“如果想要确定结论，还需要添加研究，探究除了低水平的胆固醇外其他心衰初级预防中的方法”
Am Heart J 2008; Advance online publication.
《美国心脏杂志》2008年，在线出版物 |
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发表于 2008-3-22 16:29:47
