补充多种微量元素降低婴儿早期死亡率!

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Multiple Micronutrient Supplementation Cuts Early Infant Mortality

NEW YORK (Reuters Health) Jan 17 - Maternal supplementation with multiple micronutrients (MMN) rather than with just iron and folic acid (IFA) can reduce early infant deaths, particularly in women who are undernourished or anemic, new research shows.

The Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT) involved 31,290 pregnant women in Indonesia who, through their midwives, were randomized to receive MMN or IFA supplementation. The supplements were to be taken daily during pregnancy through 90 days postpartum.

Overall, infants of MMN-treated mothers were 18% less likely to die within 90 days of birth than were infants of IFA-treated mothers: infant mortality rates were 35.5 vs. 43.0 deaths per 1000 livebirths in the two groups, respectively, lead author Dr. Anuraj Shankar, from the University of Mataram in Indonesia, and colleagues write in the January 19th issue of The Lancet.

The MMN-related reductions in infant mortality for undernourished and anemic mothers were 25% and 38%, respectively.

MMN use was also associated with an 11% reduction in combined fetal loss and neonatal death. For undernourished or anemic women, the reductions were 15% and 29%, respectively.

MMN-treated mothers were 14% less likely than controls to have a low birthweight infant. Once again, the risk reduction seen with MMN use was even higher for anemia mothers -- 33%.

\"We feel that the results of SUMMIT provide a strong basis to pursue larger effectiveness trials of maternal MMN supplements,\" Dr. Zulfiqar A. Butta and Dr. Batool Azra Haider, from Aga Khan University in Karachi, Pakistan, comment in a related editorial. Given that there has been some controversy regarding whether MMN supplements actually improve outcomes, \"these trials must be done in programmatic settings with strong monitoring and evaluation components.\"

Lancet 2008;371:186-187,215-227.
最新研究表明，母亲（尤其是营养不良和贫血妇女）补充多种微量元素（MMN）而不是单单补充铁和叶酸（IFA）能降低婴儿早期死亡率。