恐怖活动、急性应激和心血管健康

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——9.11 3年后的全国性研究
Terrorism, Acute Stress, and Cardiovascular Health

A 3-Year National Study Following the September 11th Attacks

E. Alison Holman, FNP, PhD; Roxane Cohen Silver, PhD; Michael Poulin, PhD; Judith Andersen, PhD; Virginia Gil-Rivas, PhD; Daniel N. McIntosh, PhD

Arch Gen Psychiatry. 2008;65(1):73-80.

Context The terrorist attacks of 9/11 (September 11, 2001) present an unusual opportunity to examine prospectively the physical health impact of extreme stress in a national sample.

Objective To examine the degree to which acute stress reactions to the 9/11 terrorist attacks predict cardiovascular outcomes in a national probability sample over the subsequent 3 years.

Design, Setting, and Participants A national probability sample of 2729 adults (78.1% participation rate), 95.0% of whom had completed a health survey before 9/11 (final health sample, 2592), completed a Web-based assessment of acute stress responses approximately 9 to 14 days after the terrorist attacks. Follow-up health surveys reassessed physician-diagnosed cardiovascular ailments 1 (n = 1923, 84.3% participation rate), 2 (n = 1576, 74.2% participation rate), and 3 (n = 1950, 78.9% participation rate) years following the attacks.

Main Outcome Measures Reports of physician-diagnosed cardiovascular ailments over the 3 years following the attacks.

Results Acute stress responses to the 9/11 attacks were associated with a 53% increased incidence of cardiovascular ailments over the 3 subsequent years, even after adjusting for pre-9/11 cardiovascular and mental health status, degree of exposure to the attacks, cardiovascular risk factors (ie, smoking, body mass index, and number of endocrine ailments), total number of physical health ailments, somatization, and demographics. Individuals reporting high levels of acute stress immediately following the attacks reported an increased incidence of physician-diagnosed hypertension (rate ratios, 2.15 at 1 year and 1.75 at 2 years) and heart problems (rate ratios, 2.98 at 1 year and 3.12 at 2 years) over 2 years. Among individuals reporting ongoing worry about terrorism post-9/11, high 9/11-related acute stress symptoms predicted increased risk of physician-diagnosed heart problems 2 to 3 years following the attacks (rate ratios, 4.67 at 2 years and 3.22 at 3 years).

Conclusion Using health data collected before 9/11 as a baseline, acute stress response to the terrorist attacks predicted increased reports of physician-diagnosed cardiovascular ailments over 3 years following the attacks.

Author Affiliations: Program in Nursing Science (Dr Holman) and Departments of Psychology and Social Behavior and Medicine (Dr Silver), University of California, Irvine; Center for Behavioral and Decision Sciences in Medicine, University of Michigan, Ann Arbor (Dr Poulin); Department of Veterans Affairs Medical Center, Syracuse, New York (Dr Andersen); and Departments of Psychology, University of North Carolina, Charlotte (Dr Gil-Rivas), and University of Denver, Denver, Colorado (Dr McIntosh).

http://archpsyc.ama-assn.org/cgi/content/short/65/1/73
  结果 对9/11急性应激反应使随后3年的心血管疾病发生率增加53％，即便是校正了9/11以前的心血管和精神健康状况、对袭击的暴露程度、心血管危险因素（比如吸烟、体重指数、内分泌疾病）、总的生理疾病数、躯体化和人口统计资料。袭击后即刻急性应激水平升高导致超过2年的内科医师诊断的高血压发生率升高（比值比，第1年2.15、第2年1.75）和心脏疾病发生率升高（比值比，第1年2.98、第2年3.12）。9/11后持续焦虑者9/11相关的急性应激症状预示着袭击后2-3年内科医师诊断的心脏疾病危险增高（比值比，第2年4.67、第3年3.22）。