脊柱损伤瘫痪有望恢复？

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Scientists Say Rewiring Helps Mice Paralyzed by Spinal Injuries Walk Again

Scientists said they've found a way to enable mice paralyzed by spinal cord injuries walk again, according to a study published in this week's edition of the journal Nature Medicine.

Researchers from the University of California Los Angeles say mice given partial spinal cord injuries were able to regain the ability to walk within eight to 10 weeks, although not as well as before the injury, according to a Reuters report.

Spinal cord damage obstructs the pathways the brain uses to transit messages to the nerve cells that control walking. Current thinking is that the only way someone with a spinal cord injury could walk again is to regrow the long nerve highways linking the brain and base of the spinal cord.

But scientists from UCLA found that detouring the \"walking\" messages around the injury helped the mice regain some mobility.

Using a traffic analogy Dr Michael Sofroniew, lead author and a professor of neurobiology at the David Geffen School of Medicine at UCLA, told Reuters, \"If you have a big freeway going somewhere, then that's the fastest route to take. If that gets blocked and you can't get through, an alternative way might be simply to get off the freeway and use shorter interconnected side streets to get around.\"

http://www.foxnews.com/story/0,2933,320537,00.html
本周版“自然医学杂志”上，科学家们称，他们已经发现了一种能够让因脊髓外伤而瘫痪的小鼠重新行走的方法。
路透社报道，洛杉矶.加利佛尼亚大学的研究人员们说，不完全脊髓外伤小鼠能够在8-10周内重获行走能力，尽管不如伤前。
脊髓损伤阻碍了脑部控制运动的神经元向脊髓传送信息的通道。目前认为，唯一能让脊髓损伤患者重新站起的方法是，重新建立连接大脑与脊髓基质的神经通路。

但是UCLA的科学家们发现，让“行走”信息绕道而行可以让小鼠重获部分移动能力。

来自UCLA，David Geffen医学院的，神经生物学教授及主编Michael Sofroniew博士对路透社说，“就好比是道路交通，如果你可以通过一条高速公路到达某地，这是条捷径。如果这条路给堵了，你就过不去了，就要换种方法来通过这条高速公路；嫁接一条短的桥样旁路，以跨接，并通过堵塞路段。”