This toxicological profile is prepared in accordance with guidelines developed by the Agency for
Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The
original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised
and republished as necessary.
The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health
effects information for the hazardous substance described therein. Each peer-reviewed profile identifies
and reviews the key literature that describes a hazardous substance's toxicologic properties. Other
pertinent literature is also presented, but is described in less detail than the key studies. The profile is not
intended to be an exhaustive document; however, more comprehensive sources of specialty information
are referenced.
The focus of the profiles is on health and toxicologic information; therefore, each toxicological
profile begins with a public health statement that describes, in nontechnical language, a substance's
relevant toxicological properties. Following the public health statement is information concerning levels
of significant human exposure and, where known, significant health effects. The adequacy of information
to determine a substance's health effects is described in a health effects summary. Data needs that are of
significance to protection of public health are identified by ATSDR and EPA.
Each profile includes the following:
(A) The examination, summary, and interpretation of available toxicologic information and
epidemiologic evaluations on a hazardous substance to ascertain the levels of significant
human exposure for the substance and the associated acute, subacute, and chronic health
effects;
(B) A determination of whether adequate information on the health effects of each substance is
available or in the process of development to determine levels of exposure that present a
significant risk to human health of acute, subacute, and chronic health effects; and
(C) Where appropriate, identification of toxicologic testing needed to identify the types or levels
of exposure that may present significant risk of adverse health effects in humans.
The principal audiences for the toxicological profiles are health professionals at the Federal, State,
and local levels; interested private sector organizations and groups; and members of the public.
This profile reflects ATSDR’s assessment of all relevant toxicologic testing and information that
has been peer-reviewed. Staff of the Centers for Disease Control and Prevention and other Federal
scientists have also reviewed the profile. In addition, this profile has been peer-reviewed by a
nongovernmental panel and is being made available for public review. Final responsibility for the
contents and views expressed in this toxicological profile resides with ATSDR.
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发表于 2008-1-4 08:18:33