study on propolis

yct01

The purpose of this study was to develop stable topical formulations added with propolis extract in an attempt to prevent
or treat the diseases occurring in skin caused by UV radiation. The antioxidant activity using a chemiluminescent method was used to evaluate
the functional stability and the permeation/retention in skin of these formulations. In the long-term stability study, the formulations were stored at
15±2 ◦C/AH and at 38±2 ◦C/70% RH for 180days. It was found in this study, that the formulations prepared with honey showed functional
and physical stability in the period of study. In addition, this formulation presented good results in the percutaneous study, allowing the antioxidant
compounds present in the propolis extract to reach lower layers in pig ear skin and in the whole hairless mice skin . In the in vivo study, it was also suggested that this formulation may be effective in protecting skin from UVB
photodamage, nevertheless other assays need to be done in order to have a complete understanding of the protective effect of formulations added
with propolis extract.