3D成像：让乳腺癌误诊减少半数

hy2007

3-D mammography cuts false-positive rates by half

CHICAGO (Reuters Health) - Stereoscopic digital mammography, which gives a 3-dimensional view of the inner structures of the breast, cuts the number of falsely diagnosed tumors in half, compared with conventional mammography, researchers reported here this week.

Preliminary results with stereoscopic digital mammography were described at the meeting of the Radiological Society of North America by one of its developers, Dr. David J. Getty of BBN Technologies of Cambridge, Massachusetts.

The technique involves capturing two images 6 to 10 degrees apart that are cross-polarized and then superimposed, in much the same way as two images are used to create 3-D movies.

\"Two-dimensional imaging masks subtle lesions,\" Getty explained. \"With 3-D mammography, this is greatly reduced. Lesions can be seen as lying at different depths.\"

In the study, 1,093 women referred for evaluation of suspected breast cancer were each examined with conventional mammography and the stereoscopic digital technique.

There were 259 abnormalities detected with one or both approaches, with 109 true positives and 150 false positives. Compared with conventional mammography, stereoscopic digital imaging reduced the false-positive rate by 49 percent.

\"A 15 percent drop would have been a significant reduction, so this is a highly statistically significant finding,\" Getty said. \"It cuts the false-positive rate in half, resulting in fewer patient recalls, less anxiety and less cost.\"

Data on approximately 1500 women are expected to be analyzed by the end of the year, at which point the trial will be complete.

http://www.reuters.com/article/healthNews/idUSCOL97439820071129

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[转贴]芝加哥（路透社健康新闻）－本周有研究者报道将乳腺内部结构以三维视图显示的立体数字化钼靶摄像与传统钼钯摄像比较，可将乳腺癌误诊数减半。

立体数字化钼靶摄像原理为6-10度正交偏振的分别捕获两幅图片并加以重叠，同样方法常用于三维电影的制作。

来自麻萨诸塞州剑桥工学院David J. Getty博士，是立体数字化钼靶机研发者之一。他在北美放射学协会举办的会议上汇报了立体数字化钼靶摄像对比研究的初期结果。Getty解释道“二维成像掩盖了一些不易成像的病变区，利用三维成像，这些病变区的漏诊将会明显减少，不同深度的病变区在图像上一目了然”。

在该研究中，1093可疑乳腺癌患者均给予传统钼钯摄像和立体数字化钼钯摄像。共259例患者一项或两项检查异常，其中109例为乳腺癌患者（真阳性），150例为非乳腺癌患者（假阳性）。与传统钼钯摄像比较，立体数字化钼钯摄像降低了49%的假阳性率。

Getty博士说“降低15%的假阳性率已为显著降低，因此本研究结果（降低49%）在统计学上有非常显著的意义。该技术降低乳腺癌诊断假阳性率近半，必将使患者更少需再次召回检查，使患者更少焦虑和更少花钱”。

期望在本年底完成约1500例女性可疑乳腺癌患者的检查对比分析，届时试验也将结束。