解析Measlesj结构提供新药设计指南

hxq2007

Measles Structure Offers Drug Design Guide

Despite extensive vaccination efforts, measles remains a dangerous, highly contagious disease worldwide, infecting some 20 million people a year. Structural information about the protein the virus uses to attach itself to its target cells could provide a new strategy to fight infection. A new structure from Howard Hughes Medical Institute (HHMI) researchers reveals important features of the propeller-like molecule, known as measles virus hemagglutinin (MVH), that drug designers will need to consider as they attempt to thwart infection by interfering with the virus's grip on its host cell.

Researchers Leremy Colf and Sean Juo determined the structure in the laboratory of Howard Hughes Medical Institute investigator Christopher Garcia. The researchers published their findings November 18, 2007, as an advance online publication of the journal Nature Structural and Molecular Biology. They are at the Stanford University School of Medicine.

http://www.hhmi.org/news/garcia20071118.html