一段医学翻译,大家帮忙

In the liver, LRP-1 mediates the bulk clearance of lipoproteins, plasma proteases, protease-inhibitor complexes, and A (1– 40) shown in this study (Nykjaer and Willnow, 2002). For example, LRP-1 mediates the hepatic uptake of chylomicron remnants, the lipoprotein that shuttles dietary lipids from the intestine to the liver. Therefore, insulin regulation of LRP-1 is likely to play a physiological role in maintenance of systemic lipid homeostasis in response to fed conditions by facilitating the hepatic clearance of the dietary lipids, which are increased by nutrient intake. This also could explain the hyperlipidemia associated with DM after the attenuation of LRP-1-dependent uptake.