阿司匹林在伴有ASC病史糖尿病患者的作用

readok2009

Aspirin and mortality in patients with Diabetes Mellitus sustaining Acute Coronary Syndrome
ABSTRACT
Objective: Comparison of mortality reduction associated with secondary prevention in patients with and without diabetes mellitus (DM) after acute coronary syndrome (ACS).

Research design and methods: Cohort study involving 2499 patients with ACS recruited from 11 UK hospitals. Multivariable analysis comparing all cause mortality risk reduction associated with pharmacologic agents in patients with and without DM.

Results: Aspirin was not associated with significant mortality benefit in DM sufferers (95% CI 0.50-1.08); non-diabetic patients derived a 48% mortality reduction (p<0.001). The interaction between DM and aspirin use was statistically significant (p=0.037), indicating patients with DM experience less effective mortality reduction from aspirin use.

Conclusions: Aspirin, but not other secondary prevention agents, is associated with less effective mortality reduction in patients with DM and unstable coronary artery disease.
http://care.diabetesjournals.org/cgi/content/abstract/dc07-1745v1