蛋白质序列分析

heathy

蛋白质序列分析
Compute pI/Mw- http://www.expasy.ch/ch2d/pi_tool.html（is a tool which allows the computation of the theoretical pI(isolectric point) and Mw (molecular weight) for a list of SWISS-PROTentries or for a user entered sequence）蛋白质序列的理论等电点、分子量的计算
CATH- http://www.biochem.ucl.ac.uk/bsm/cath（Protein Structure Classification CATH is a hierarchicalclassification of protein structural relationships derived using acombination of automatic and manual methods. CATH identifies thedifferent groups in the classification by a unique CATH number, as wellas a descriptive name） 通过自动、手动方式进行蛋白质结构相关性的系统分类，
CATH是以下四个单词的第一个字母的组合
  Class类 ——（The highest level of the classification, derived from gross secondary structure content） 源于二级结构的最高级别的分类
  Architecture构造——（ Description of the gross arrangement of secondary structures. Independent of topology）独立于拓扑结构的二级结构排列描述。
  Topology拓扑结构——（ Topological description, with reference to previously observed structures and well-known folds）参照已知的折叠及观测的结构进行拓扑分析
  Homology 同源——（ Discriminationbetween structures with same topology, but more diverse structuresOften correlates with functional homology）结构间相同的拓扑布局、不同的二级结构（与功能相似性相关）描述
CRASPhttp://wwwmgs.bionet.nsc.ru/Programs/CRASP/default.htm Correlation Analysis of Sequences of Proteins 蛋白质序列的相关分析
FPAThttp://www.ibc.wustl.edu/fpat/-an easy way to search a molecular sequence database for patterns. 检索分子序列数据库模式的简易方法
Hydropathy Plot (GIF image) http://www.bmb.psu.edu/nixon/webtools/hydro/default.htm - for the drawing of hydropathy plot. 绘制亲疏水图
MOTIF http://www.genome.ad.jp/SIT/MOTIF.html- Search Patterns in Protein Sequences 蛋白质序列模式检索
RandSeq http://www.expasy.ch/sprot/randseq.html- Random protein sequence generator 随机的蛋白质序列生长子
REPRO- http://www.embl-heidelberg.de/repro/repro_info.htmlA service for the recognition of protein sequence repeats蛋白质重复片断识别服务器
SALSA-http://dna.uio.no/salsa/ Search DNA and Protein Databases for Sequence Similarities 蛋白质、核酸序列相似性检索
SignalPhttp://www.cbs.dtu.dk/services/SignalP/ 在不同的物种中预测信号肽及酶切位点
SIM-http://expasy.hcuge.ch/sprot/sim-prot.html 由用户定义的最佳两序列对比
TMpredhttp://ulrec3.unil.ch/software/TMPRED_form.html - 蛋白质跨模区预测、定位，该方法基于统计学结果，通过权重矩阵打分进行预测分析
Coils http://ulrec3.unil.ch/software/COILS_form.html- 对比分析具有双股卷曲结构的序列同源性打分，进而计算适于采用该结构的序列的几率
GuessProt http://www.expasy.ch/www/guess-prot.html- 选择SwissProt蛋白的等电点、分子量
MassSearch http://cbrg.inf.ethz.ch/subsection3_1_3.html- 蛋白质消化后的聚集检索
Phospepsorthttp://genome.eerie.fr/gcg/phospepsort-query.html - 磷酸化位点分类
SAPS http://ulrec3.unil.ch/software/SAPS_form.html- 蛋白质序列统计分析
Sleuth http://www.bioon.com/molebio/pro ... du/pub/sleuth/data- 氨基酸构象及可及性分析
PEDANT-http://pedant.mips.biochem.mpg.de/frishman/pedant.html 蛋白质提炼
PROVE http://www.ucmb.ulb.ac.be/%7Ejoan/survol/form.html- 蛋白质原子体积计算
Naccess (ASA for proteins) http://sjh.bi.umist.ac.uk/naccess.html 利用Lee & Richards方法描述分子表面性质的计算程序，能够计算蛋白质的表面可及性