儿童肾移植免疫抑制的新趋势

hy2007

Titlie：New trends in immunosuppression for pediatric renal transplant recipients.
Author：Paul Atkison and Guido Filler.
Source：Current Opinion in Organ Transplantation. 12(5):509-514, October 2007
Purpose of the review：Rapidly growing information, published in a large variety of
journals, poses a challenge to pediatric transplant physicians. This review aims at summarizing the most important manuscripts published over the last 1–2 years.
Recent findings：While rejection rates remain low with current immunosuppressive regimes, the focus shifts towards improvement of long-term outcome and reduction of serious adverse events. While effective and safe calcineurin-inhibitor minimization protocols are emerging, it may be too early for calcineurin-inhibitor avoidance. Significant
randomized controlled clinical trials question the efficiency of basiliximab induction therapy. Nonadherence remains a major challenge particularly in adolescent renal
transplant recipients.
Summary
The search for fewer nephrotoxic immunosuppressive regimes after pediatric renal
transplantation continues.