OTC Anti-Aging Products: Hype or Hope?
抗衰老非处方药：骗局还是希望？
While the potential benefits are many, clinical studies are few
虽然很有潜力，相关临床研究却很少
NEW YORK, Aug. 13/PRNewswire-USNewswire/—Findings from a study released today revealed that a limited amount of clinical research exists to prove the effectiveness of many over-the-counter (OTC) anti-aging products. The study is published in the July/August 2007 issue of the Aesthetic Surgery Journal, the official peer-reviewed journal of the American Society for Aesthetic Plastic Surgery (ASAPS).
纽约，8月13日/PRNewswire-USNewswire/—今天公布的研究发现揭露：只有少数的临床研究证明抗衰老非处方药是有效的。文章刊登在2007年7/8月份的《Aesthetic Surgery（美容外科）》杂志上，它是由美国整形外科协会(ASAPS)主办的官方评论性杂志。
OTC anti-aging products represent a billion dollar industry: wrinkle creams have been marketed to the American public since the early 19th century, and Americans spent more than $2 billion on these products in 2000 alone. While a limited body of evidence exists to prove the efficacy of many of these products, their popularity continues to increase.
抗衰老非处方药代表的是一个市值十亿美元的产业：去皱霜自19世纪早期已经开始面向美国大众销售，仅2000年，美国人在抗衰老非处方药上就花了20多亿美元。尽管其中的一些产品的有效性缺乏证据支持，然而它们的受欢迎程度仍持续增高。
\"This study underscores the need for much greater study of, and public education on, the effectiveness of OTC anti-aging products,\" said Timothy A. Miller, MD, Chief of Plastic Surgery at UCLA, lead author of the study.\"Although there are a number of beneficial OTC remedies in existence, for many patients, prescription-strength or surgical procedures may be necessary to achieve desired results.\"
医学博士Timothy A. Miller在文中强调需要有关抗衰老非处方药有效性的更大规模的研究和公众教育。他是文章的第一作者，加州大学洛杉矶分校整形外科主任。虽然有一些抗衰老非处方药是有效的，但对许多病人来说，必须使用处方药或进行手术才能达到它们所期望的效果。
The study consisted of a review of existing research on ingredients commonly found in OTC anti-aging creams. Key compounds under review included vitamins, antioxidants, alpha-hydroxyl acids, moisturizers,pentapeptides and botanicals. Of these, Vitamin C, alpha-hydroxyl acids and pentapeptides were shown to be the most extensively researched with proven anti-aging benefits.
文章对现有的关于抗衰老非处方药常见成分的研究进行了回顾。主要成分包括：维生素、抗氧化剂、果酸、湿润剂、胸腺五肽以及植物制剂。其中，维生素C、果酸、胸腺五肽的研究最为广泛，而且被证明具有抗衰老作用。
Vitamin A, or retinols have shown great promise, however their effects have only been proven in prescription-strength formulations; OTC benefits have not been determined. Minimal studies have been performed on Vitamin B,though what evidence does exist is promising. Moisturizers have not been extensively researched, but have been shown to improve the hydration and appearance of skin.
维生素A（或称视黄醇）前景广阔，但仅在处方剂量被证明具有抗衰老作用；其OTC产品的抗衰老作用还不确定。虽然已经完成的只是有关维生素B的小型试验，但证据表明维生素B是有希望的。关于湿润剂的研究也不多，但也显示出了促进水合作用和改善皮肤外观的作用。
Botanicals such as grape seed extract, soy compounds, green tea and Gingko biloba are relatively new in the market and have gained great popularity in recent years, but their healing qualities have yet to be proven through randomized, placebo-controlled human trials. Many cell culture and animal experiments have been conducted to investigate the efficacy of these botanical compounds, however, indicating the potential for many beneficial effects such as increased collagen expression, improved antioxidant activity, accelerated healing and enhanced hydration.
植物制剂（诸如葡萄种子提取物、大豆化合物、绿茶以及银杏叶等）是相对较新的上市产品，在近年来深受欢迎，但其治疗作用仍未得到随机对照人体试验的证实。虽然进行了许多考察这些植物化合物的有效性的细胞培养试验和动物试验，但仅表明他们具有一些潜在的治疗作用，诸如促进胶原表达，提高抗氧化剂的活性，促进愈合以及增强水和作用。
\"Consumers need to be realistic about the outcomes they can expect from OTC anti-aging creams, at least until solid clinical evidence of their efficacy exists,\" adds Foad Nahai, MD, Atlanta plastic surgeon, President of ASAPS and Associate Editor of ASJ. \"No matter what the treatment —OTC, prescription or surgical procedure -- it is always important for patients to educate themselves and discuss options with their doctor.\"
医学博士Foad Nahai补充道：“消费者应该回归现实，不能奢望抗衰老非处方药会有多好的效果，至少直到具有可靠的有效性的临床证据。对于患者来说，无论采用何种治疗（OTC药品、处方药或者手术治疗），自学并与医生讨论自己的选择总是很重要的”Foad Nahai博士是一名整形外科医生，他也是美国整形外科协会主席，《美容外科》志的特约编辑。 |
发表于 2007-9-20 01:11:09
