Drug Metabolism and Transport: Molecular Methods and Mechanisms

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Drug Metabolism and Transport: Molecular Methods and Mechanisms (Methods in Pharmacology and Toxicology)
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Publisher:  Humana Press
Number Of Pages:  400
Publication Date:  2004-09-24
Sales Rank:  1349425
ISBN / ASIN:  1588293246
EAN:  9781588293244
Binding:  Hardcover
Manufacturer:  Humana Press
Studio:  Humana Press
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Book Description:

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.


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