黄酮醇预防胰腺癌（摘要）

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题目：黄酮醇预防胰腺癌：多种族队列研究

作者：N鰐hlings U, Murphy SP, Wilkens LR, Henderson BE, Kolonel LN.

来源：流行病学. 2007 年八月9号

摘要：仅仅有几个前瞻性的研究把黄酮醇作为癌症的危险因素，这些研究中均没有胰腺癌。作者在这个多种族的队列研究中对183，518名参与者应用了三种黄酮醇（橡黄素，山奈酚，杨梅酮）并检测其与胰腺癌的发生上的相关性。参考数据是在1993-1996年在夏威夷和加州收集的。该研究通过用定量的进食频率调查表对饮食进行评估. 在其后的8年的随访中，529名患了外分泌的胰腺癌。多元X回归模型用于评估相关的危险因素。黄酮醇的摄入能降低胰腺癌的发生（最高的相关危险因素与最低的相关的危险因素比值是0.77，95%的可信区间是：0.58，1.03；P值是 0.046）。在三个黄酮醇的摄入组中橡黄素组能最大的降低相关的危险因素（相关危险因素的比值是0.78，95%的可信区间：0.58，1.05；P：0.017），在目前吸烟者中总体的黄酮醇，橡黄素，山奈酚，杨梅酮均能降低其胰腺癌的发生（相关的危险因素比值分别是0.41，0.55，0.27，0.55），但是对于以前吸烟的人的作用尚不明确。这项研究为我们黄酮醇预防胰腺癌提供了证据，尤其对于正在吸烟的人。

原文如下：
Title：Flavonols and Pancreatic Cancer Risk: The Multiethnic Cohort Study.

Author:N鰐hlings U, Murphy SP, Wilkens LR, Henderson BE, Kolonel LN.

Resource: Am J Epidemiol. 2007 Aug 9

Abstract: Only a few prospective studies have investigated flavonols as risk factors for cancer, none of which has included pancreatic cancer. The latter is usually fatal, rendering knowledge about prevention particularly important. The authors estimated intakes of three flavonols-quercetin, kaempferol, and myricetin-for 183,518 participants in the Multiethnic Cohort Study and examined associations with incidence of pancreatic cancer. Baseline data were collected in Hawaii and California in 1993-1996. Diet was assessed by using a quantitative food frequency questionnaire. During 8 years of follow-up, 529 cases of exocrine pancreatic cancer occurred. Multivariate Cox regression models were calculated to estimate relative risks. Intake of total flavonols was associated with a reduced pancreatic cancer risk (relative risk for the highest vs. lowest quintile = 0.77, 95% confidence interval: 0.58, 1.03; p trend = 0.046). Of the three individual flavonols, kaempferol was associated with the largest risk reduction (relative risk = 0.78, 95% confidence interval: 0.58, 1.05; p trend = 0.017). Total flavonols, quercetin, kaempferol, and myricetin were all associated with a significant inverse trend among current smokers (relative risks for the highest vs. lowest quartile = 0.41, 0.55, 0.27, 0.55, respectively) but not never or former smokers. This study provides evidence for a preventive effect of flavonols on pancreatic cancer, particularly for current smokers.