Fine-Tuning of RNA Functions by Modification and Editing (Topics in Current G

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Fine-Tuning of RNA Functions by Modification and Editing (Topics in Current Genetics)

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Product Description

Naturally occurring RNA always contains numerous biochemically altered nucleotides. They are formed by enzymatic modification of the primary transcripts during the complex RNA maturation process designated RNA modification. A large number of enzymes catalyzing the formation of these modified nucleosides or converting one canonical base into another at the posttranscriptional level have been studied for many years, but only recently have systematic and comparative studies begun. The functions of individual enzymes and/or the modified/edited nucleosides in RNA, however, have remained largely ignored.


This book provides advance information on RNA modification, including the associated editing machinery, while offering the reader some perspective on the significance of such modifications in fine-tuning the structure and functions of mature RNA molecules and hence the ability to influence the efficiency and accuracy of genetic expression. Outstanding scientists who are actively working on RNA modification/editing processes have provided up-to-date information on these intriguing cellular processes that have been generated over the course of millions of years in all living organisms. Each review has been written and illustrated for a large audience of readers, not only specialists in the field, but also for advanced students or researchers who want to learn more about recent progress in RNA modification and editing.

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Product Details
Hardcover: 442 pages
Publisher: Springer; 1 edition (June 1, 2005)
Language: English
ISBN-10: 3540244956
ISBN-13: 978-3540244950
Product Dimensions: 8.9 x 6.2 x 1.1 inches



Abstract
　　　1 Short historical background
　　　　　1.1 Discovery of modified nucleosides
　　　　　1.2 Discovery of RNA modification enzymes
　　　　　1,3 RNA editing, a new concept
　　　　　1.4 Different mechanisms for RNA modification/editing
　　　　　1.5 Localization and temporal order of RNA modification/editing
　　　2 Unraveling the functions of RNA modification/editing enzymes
　　　　　2.1 Need to expand the limited RNA vocabulary
　　　　　2.2 Not all nucleosides in RNAs are fully modified/edited
　　　　　2.3 Fine-tuning of RNA structure and function
　　　　　2.4 Few modifying enzymes play a dual role in RNA maturation
3 Conclusion and further prospects: unravel biological complexity
Acknowledgements
References
Biosynthesis and function of tRNA wobble modifications
　Tsutomu Suzuki
　　Abstract
　　　1 Introduction
　　　　　1.1 The wobble rule and the role of RNA modification in decoding
　　　　　1.2 Modified uridines
　　　　　1.3 Modified adenosine (inosine)
　　　　　1.4 Modified guanosines
　　　　　1.5 Modified cytidines
2 Ribonucleome analysis: systematic identification of genes involved in RNA modifications by reverse genetics methods
　　　　　2.1 Non-essential RNA modifications
　　　　　2.2 Essential RNA modifications
3 Biosynthesis of lysidine
　　　　　3.1 Identification of an essential gene responsible for lysidine formation
　　　　　3.2 In vitro lysidine synthesis by TilS
　　　　　3.3 Mechanism of lysidine synthesis
　　　　　3.4 Direct conversion of the amino acid specificity of tRNA\"e due to the lysidine modification
　　　　　3.5 The lysidine modification is essential for decoding AUA codons in vivo
3.6 Recognition of tRNAlie by TilS
3.7 Evolution of wobble modifications and genetic code assignment of AUA codon
4 Wobble modification and subcellular localization of tRNAs
4.1 Post-transcriptional modifications control the subcellular localization of RNA molecules
4.2 Role of wobble modifications in the tRNA sorting mechanism in Leishmania tarentolae
5 Mitochondrial wobble modifications and human diseases
　　　　　5.1 Mitochondrial wobble modifications and the minimal decoding system
　　　　　5.2 Biosynthesis of taurinomethyluridines
　　　　　5.3 Role of mitochondrial tRNA-specific 2-thiouridylase (MTU 1) in the synthesis of xmSs2U
　　　　　5.4 Wobble modification defects in mitochondrial diseases
　　　　　5.5 Molecular pathogeneses of mitochondrial diseases
6 RNA modification disorders as a cause of human diseases
7 Conclusion and outlook
　　　　　7.1 Amino acid conjugation involved in RNA modifications
Acknowledgement
References
Editing and modification in trypanosomatids: the reshaping of non-coding
RNAs
Mary Anne T. Rubio and Juan D. Alfonzo
Abstract
1 Introduction
2 RNA modification and trans-splicing
3 RNA editing and protein secretion
4 Role of modifications on sub-cellular localization oftRNAs
5 The story oftRNA~ in trypanosomatids: where editing meets modification
6 Concluding remarks
Acknowledgements
References
Transfer RNA modifications and modifying enzymes in Saccharomyces
cerevisiae
Marcus J.O. Johansson and Anders S. Bystr6m
Abstract
1 Introduction
2 tRNA maturation
3 Modified nucleosides in tRNA
4 Genes required for formation of modified nucleosides in tRNA
　　　　　4.1 Pseudouridine
　　　　　4.2 Dihydrouridine
Biosynthesis and function of 1-methyladenosine in transfer RNA
The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA
Role of the 5'-cap in he biogenesis of spliceosomal snRNPs
Role of a conserved pseudouridine im U2 snRNA on the structural and electrostatic features of the spliceosomal pre-mRNA branch site
Mechanisms and functions of RNA-guided RNA modification
Conserved rib osoma RNA modification and their putative roles in ribosome biogenesis and translation
Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics
Transational Recoding and RNA Modifications
Adenosine to inosine RNA editing in animal cells
Mammalian C to U editing
Transfer RNA modifications and DNA editing in HIV-1 reverse transcription
Um34 in selenocysteine tRNA is required for the expression of stress-related selenoproteins in mammals
Index

本书围绕RNA修饰编辑过程进行基因表达精细调控分子机制的深入分析，是相关研究者的重要参考。原版书2400元在当当销售，本人多方求找得获电子版，虽在一些知名论坛和网盘中有帖子介绍，但是链接多数已过期，遂自行整理发布于此，供大家择用~

链接见回复贴

zhxlwl

游客，本帖隐藏的内容需要积分高于 5 才可浏览，您当前积分为 0

orientsir

游客，本帖隐藏的内容需要积分高于 5000 才可浏览，您当前积分为 0

josephe

不知原创的内容是啥？

云之惑

总算看出来了，原来是分享书籍！

josephe

引用第4楼云之惑于2010-03-01 22:11发表的 呵呵！~ :
总算看出来了，原来是分享书籍！

现在看出来也不晚。

hanvool

这本书对于研究细胞代谢工程（号称是：第三代基因工程技术）的人员是比较有用，赵师傅是这方面的专家，应该多发表点意见

josephe

引用第6楼hanvool于2010-03-02 11:19发表的 Re :
  这本书对于研究细胞代谢工程（号称是：第三代基因工程技术）的人员是比较有用，赵师傅是这方面的专家，应该多发表点意见

http://rapidshare.com/files/2177 ... FubMoaEdToiCuGe.rar
pass: gigapedia

hanvool

赫赫，你呀。我今年听到最响亮的声音：

引用第32楼josephe于2010-03-01 23:31发表的 :
偶的电子书都放在人家的服务器上。  

好书我收下了，虽然看不懂，也不能马上用到。