Objective In order to study the differentiation molecular mechanism of acute promyelocytic leukemia (APL) cells induced by TanⅡA in vitro, and to provide application rationales of TanⅡA to APL patient treatment, the differentiation expression in aspects of cell biology and molecular biology induced by TanⅡA were compared with that induced by all-trans retinoid acid (ATRA) and arsenic trioxide (As_2O_3). 2 Materials and methods 2.1 Cell culture Logarithmically growing NB_4 cell were c...
发表于 2008-4-18 08:33:26