皮肤癌，结肠癌综合征可能相关

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Skin cancer, colon cancer syndrome may be linked

NEW YORK (Reuters Health) - A syndrome that increases the risk of some skin cancers may be a subset of a syndrome that increases the risk of colon cancer, report researchers from The Ohio State University, Columbus.

Some people with Lynch syndrome -- an inherited condition that predisposes a person to colon cancer -- are also at greater risk for developing certain skin cancers, a condition known as Muir-Torre syndrome, Dr. Albert de la Chapelle and colleagues explain in the Journal of the National Cancer Institute for February 20.

They found that the skin lesions in patients with Muir-Torre syndrome are characterized by the same molecular defects as tumors in patients with Lynch syndrome.

Because skin tumors often develop before Lynch syndrome is diagnosed in these patients, \"all individuals who are diagnosed with a Muir-Torre syndrome-related skin lesions should be screened for Lynch syndrome,\" the researchers advise.

To determine the frequency of Muir-Torre syndrome in patients with Lynch syndrome, they studied 152 Lynch syndrome patients from 50 different families.

Fourteen families (28 percent) with Lynch syndrome had one family member who had a history of a Muir-Torre syndrome-related tumor (9.2 percent of 152 individuals with Lynch syndrome), leading the study team to suggest that \"Muir-Torre syndrome be defined as a variant of Lynch syndrome.\"

Dr. de la Chapelle's group also observed that 57 percent of individuals affected by both conditions presented with skin disease first.

They therefore recommend that patients with Muir-Torre syndrome undergo further genetic testing to determine if they have Lynch syndrome, in which case intensive cancer surveillance would be warranted. Conversely, they suggest that an annual skin examination is a \"reasonable strategy\" for patients with Lynch syndrome.
纽约（健康路透通讯社）-来自俄亥俄州大学的研究员报道，能增加一些皮肤癌的综合征也许能增加患结肠癌的危险。
2月20日，Albert de la Chapelle 博士和其同事在国家肿瘤组织杂志上做出解释：一使人容易患结肠癌的的遗传疾病的Lynch综合征患者，也很容易发展为某些皮肤癌，也叫做Muir-Torre综合征的一种疾病。他们发现，Muir-Torre综合征的患者的皮肤病变的特点是与Lynch综合征患者的肿瘤具有相同的分子缺陷。

他们还做出以下四种意见：
1. 建议“所有诊断为Muir-Torre综合征相关的皮肤病变患者都因该与Lynch综合征进行鉴别”。因为在Lynch综合征患者诊断之前，患者的皮肤癌经常已经进展了。
2.提出“定义Muir-Torre综合征为Lynch综合征的一种变异”。研究了来自50个不同家庭的152例Lynch综合征患者，目的是为了确定Lynch综合征患者并发Muir-Torre综合征的发生率。存在Lunch综合征疾病的14个家庭成员（28%）中，其中一例有Muir-Torre综合征相关肿瘤的病史（152例Lynch综合征患者中的9.2%）。
3.推荐Muir-Torre综合征患者在严密的肿瘤监护保证下，需进行进一步的基因检测，从而确定他们是否同时患有Lynch综合征。
4.他们提出，Lynch综合征患者须进行每年一次的皮肤检查。因为de la Chapelle博士的工作组，观察到具有两种综合征的57%患者起初有皮肤疾病。