斯坦福大学的研究人员为MS提供了个性化治疗的靶位

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Stanford researchers ID therapy targets for MS treatment
Researchers from the Stanford University School of Medicine said Sunday that they have identified therapy targets that could lead to personalized treatments for multiple sclerosis patients.
周日，来自斯坦福大学医学院的研究员声称他们已经发现了个性化治疗多发性动脉硬化的治疗靶位。
The team said it cataloged all of the brain-tissue proteins that they found were distinct to three discrete stages of multiple sclerosis.
该小组声称它归属于已经发现的脑组织蛋白，不同于多发性硬化症各个阶段的蛋白。
\"This is a gold mine,\" said Dr. Lawrence Steinman, professor of neurology and neurological sciences. \"Knowing what proteins are most important at a discrete stage of the multiple sclerosis process is the first step toward being able to 'personalize' treatment.\"
神经病学和神经科学教授Lawrence Steinman说：“这是一个新的发现。了解多发性硬化不同的进程阶段中最重要的蛋白质是通往个性化治疗的第一步。”
Steinman, whose team worked with researchers at the University of Connecticut Health Center, is one of two senior authors of an article published in the new issue of the journal Nature.
Steinman是发表在最新一期《自然》杂志上一篇文章的两位资深作者之一，他的研究小组与康涅狄格大学卫生中心的研究员联合研究。
In the study, the team found many unexpected proteins involved in the disease progression. When they tested drugs that block two of these proteins in a mouse model of multiple sclerosis, the mice improved dramatically.
在该项研究中，研究小组发现了许多意想不到的蛋白质参与了疾病的进展。在多发性硬化小鼠模型的身上，他们用药物阻断这些蛋白质中的两种蛋白，病变小鼠得到显著改善。
\"If our hypothesis is correct, the findings can be directly applied to patients,\" said Dr. May Han, a postdoctoral scholar at Stanford and co-first author of the paper. She emphasized that researchers are still very early in the process of being able to tailor drug therapies for humans.
May Han博士说：“如果我们的假设是正确的，结果可直接应用于病人”。May Han是斯坦福大学的博士后学者和这篇文章的共同首作者。她着重强调研发用于人类的药物还有很长的路要走。
In multiple sclerosis, the immune system launches an attack against the myelin sheath surrounding nerve cells, causing them to misfire. The resulting variety of neurological disorders affects more than 2.5 million people worldwide, according to the Multiple Sclerosis International Federation.
在多发性硬化症中，免疫系统会攻击神经细胞周围的髓鞘，使其受损。据多发性硬化症国际联合会报道，世界上有250多万人受到由此引发的神经紊乱。