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High Blood Pressure Predicts New-Onset Type 2 Diabetes in Women
NEW YORK (Reuters Health) Jan 18 - New findings from the Women's Health Study show that baseline blood pressure and progressive increases in blood pressure are \"strong and independent predictors\" of incident type 2 diabetes in initially healthy women.
The findings, published in the December issue of the European Heart Journal, are reported by a team from Harvard Medical School in Cambridge, Massachusetts, and led by Dr. David Conen.
The current analysis involved 38,172 women without heart disease or diabetes at baseline. The investigators stratified them into four groups according to baseline blood pressure: group 1, < 120/75 mm Hg; group 2, 120-129/75-84 mm Hg; group 3, 130-139/85-89 mm Hg; and group 4, > 140/90 mm Hg, classified as hypertensive.
The primary outcome measure was the development of type 2 diabetes, which occurred in 1,672 women during 10.2 years of follow-up.
Multivariable adjusted hazard ratios for incident type 2 diabetes were 0.66 for group 1; 1.0 for group 2, which served as the reference group; 1.42 for group 3; and 2.03 for group 4.
For women with blood pressure progression during the first 48 months of follow-up but who remained normotensive, the hazard ratio for type 2 diabetes was 1.26, and it was 1.64 for those who developed hypertension during the first 48 months, compared to women with no blood pressure progression.
\"Our study provides strong evidence that baseline blood pressure and blood pressure progression are associated with an increased risk of incident type 2 diabetes,\" Dr. Conen and colleagues conclude. \"Clinicians should be aware of these relationships to optimize the management of patients at increased risk for cardiovascular disease.\"
In an accompanying editorial, Dr. Peter M. Nilsson of Lund University in Malmo, Sweden, comments that early intervention studies are needed. The findings ideally \"would ask the question of whether lifestyle advice is superior, equal or inferior to drug therapy for cardiovascular prevention,\" he notes.
Eur Heart J 2007;28:2832-2833,2937-2943.
女性健康研究的新发现显示健康女性基础血压和血压进展是发生2型糖尿病的“强而独立的危险因子”
“我们的研究提供了强有力的证据显示基础血压和血压进展与发生2型糖尿病的危险增加相关，” Conen博士认为。“临床医生应该注意这一关系，以优化心血管疾病危险增加患者的治疗。” |
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发表于 2008-2-1 08:20:49