英译汉一句+一句，请教高手，谢谢

1. A more biological approach suggested that WHV can infect woodchuck lymphocytes in vivo.
A more biological approach 怎么翻译合适？
2. The first event in virus DNA replication accessible to experimental investigation is the conversion of the viral rcDNA genome into.
3. The removal of the covalently attached reverse transcriptase from the 5' end of minus-strand DNA is, in contrast, a unique reaction and, depending on the mechanism, has consequences for our understanding of cccDNA formation.有助于对cccDNA形成的理解？