焦虑是老年男性心肌梗死的独立危险因素

yuji8

南加利福尼亚大学的研究人员最近发现，焦虑能预测老年男性心肌梗死(MI) 的发生，且这种作用独立于其他心理社会因素和危险因素之外。研究结果将发表在2008年1月15日的J Am Coll Cardiol 。
Anxiety Characteristics Independently and Prospectively Predict Myocardial Infarction in Men

The Unique Contribution of Anxiety Among Psychologic Factors

Biing-Jiun Shen, PhD*,*, Yael E. Avivi, MS, John F. Todaro, PhD, Avron Spiro, III, PhD, Jean-Philippe Laurenceau, PhD||, Kenneth D. Ward, PhD# and Raymond Niaura, PhD?

* Department of Psychology, University of Southern California, Los Angeles, California
Department of Psychology, University of Miami, Coral Gables, Florida
Brown Medical School and Miriam Hospital, Providence, Rhode Island
Massachusetts Veterans Epidemiology Research and Information Center, Boston Veterans Administration Healthcare System, Boston, Massachusetts
|| Department of Psychology, University of Delaware, Newark, Delaware
# University of Memphis Center for Community Health, Memphis, Tennessee
?Brown Medical School and Butler Hospital, Providence, Rhode Island.

Objectives: This study investigated whether anxiety characteristics independently predicted the onset of myocardial infarction (MI) over an average of 12.4 years and whether this relationship was independent of other psychologic variables and risk factors.

Background: Although several psychosocial factors have been associated with risk for MI, anxiety has not been examined extensively. Earlier studies also rarely addressed whether the association between a psychologic variable and MI was specific and independent of other psychosocial correlates.

Methods: Participants were 735 older men (mean age 60 years) without a history of coronary disease or diabetes at baseline from the Normative Aging Study. Anxiety characteristics were assessed with 4 scales (psychasthenia, social introversion, phobia, and manifest anxiety) and an overall anxiety factor derived from these scales.

Results: Anxiety characteristics independently and prospectively predicted MI incidence after controlling for age, education, marital status, fasting glucose, body mass index, high-density lipoprotein cholesterol, and systolic blood pressure in proportional hazards models. The adjusted relative risk (95% confidence interval [CI]) of MI associated with each standard deviation increase in anxiety variable was 1.37 (95% CI 1.12 to 1.68) for psychasthenia, 1.31 (95% CI 1.05 to 1.63) for social introversion, 1.36 (95% CI 1.10 to 1.68) for phobia, 1.42 (95% CI 1.14 to 1.76) for manifest anxiety, and 1.43 (95% CI 1.17 to 1.75) for overall anxiety. These relationships remained significant after further adjusting for health behaviors (drinking, smoking, and caloric intake), medications for hypertension, high cholesterol, and diabetes during follow-up and additional psychologic variables (depression, type A behavior, hostility, anger, and negative emotion).

Conclusions: Anxiety-prone dispositions appear to be a robust and independent risk factor of MI among older men.

J Am Coll Cardiol 2008 51: 113-119.

http://content.onlinejacc.org/cgi/content/abstract/51/2/113