腹部疾病和Addison病：心心相印？

xyu201

Primary Adrenal Insufficiency Common in Celiac Disease

NEW YORK (Reuters Health) Oct 17 - Patients with celiac disease are at increased risk of Addison's disease, and the converse also appears to be true, according to Swedish and US researchers.

\"We therefore suggest screening for celiac disease in individuals with Addison's disease,\" lead investigator Dr. Peter Elfstrom told Reuters Health. \"We also recommend clinicians treating individuals with celiac disease to have an increased awareness of Addison's disease; however, the low incidence of Addison's disease overall does not merit screening all individuals with celiac disease.\"

In the September issue of The Journal of Clinical Endocrinology & Metabolism, Dr. Elfstrom of Orebro University Hospital and colleagues note that a number of studies have suggested a relationship between these conditions, but they were small in size and screened for celiac disease in patients with Addison's disease.

To investigate further, the researchers used Swedish national data to identify 14,366 people with celiac disease and compared them with 70,095 matched reference subjects.

The team found a significant relationship between celiac disease and subsequent Addison's disease (hazard ratio, 11.4). This was seen in both adults and children and held good after adjustment for diabetes mellitus and socioeconomic status.

The team also found that people with prior Addison's disease were at increased risk of celiac disease (odds ratio, 8.6). Given these findings, the investigators recommend that certain patients with one condition be screened for the other.

\"The positive association between celiac disease and Addison's disease was seen both before and after diagnosis of celiac disease,\" the researchers conclude, \"and we do not believe that one disease causes the other. Instead we suggest that our findings might be explained by the presence of shared genetic traits.\"

http://www.medscape.com/viewarticle/564432