Stem Cell and Gene-Based Therapy（干细胞和基因治疗）

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Contents
Cohen 3
2 Adult Stem Cells for Myocardial Tissue Repair
Dirk Strunk and Christof Stamm . 17
3 Regeneration of the Functional Myocardium Using Human
Embryonic Stem Cells
Oren Caspi and Lior Gepstien . 33
4 Therapeutic Angiogenesis
Shmuel Fuchs and Alexander Battler . 45
5 Cell Therapy for Heart Failure
Thorsten Reffelmann and Robert A. Kloner . 59
Section 2 Neuro
Introduction
Daniel Offen and Eldad Melamed 72
6 Cell Transplantation for Diseases of Myelin
Tamir Ben-Hur and Ofira Einstein 75
xi
7 Stem Cells as a Source for Cell Replacement in Parkinson's Disease
Daniel Offen, Yossef S. Levy, and Eldad Melamed 97
8 Cell Replacement Therapy in Acute Stroke: Current State
Yossi Gilgun-Sherki and Jonathan Y. Streifler 123
9 Gene Therapy to the Nervous System
Hillel Haim and Israel Steiner 133
Section 3 Musculoskeletal
Introduction
Zvi Nevo and Mark M. Levy . 156
10 Mesenchymal Stem Cells: Where Can You Find Them?
How Can You Use Them?
Anna Derubeis, Giuseppina Pennesi, and Ranieri Cancedda 159
11 Basic to Clinical Cartilage Engineering: Past, Present,
and Future Discussions
Mats Brittberg, Tommi Tallheden, and Anders H. Lindahl . 169
12 Cartilage
Rocky S. Tuan and Faye H. Chen . 179
13 Bone Regeneration
A.H. Reddi . 195
14 Osteoarthritis and Mesenchymal Cells - The Prospects for Repair
of the Disease by Cell Transplantation and Tissue Engineering
Dror Robinson . 203
Section 4 Kidney
Introduction
Benjamin Dekel and Yair Reisner 208
15 Progenitor Cell Therapy for Kidney Regeneration
Benjamin Dekel and Yair Reisner 209
16 Tissue Engineering - The Bladder
Anthony Atala . 225
Section 5 Eye
Introduction
Michael Belkin . 234
17 Neuroprotection in Ophthalmology: A Review
Yaniv Barkana and Michael Belkin . 237
xii Contents
Contents xiii
18 Autoimmunity for Central Nervous System Maintenance,
Regeneration, and Renewal: Development of a T Cell-Based
Vaccination Against Neurodegeneration
Michal Schwartz and Jonathan Kipnis 251
19 Retinal Repair by Stem Cell Transplantation
Jeffrey H. Stern, Sally Temple, and Soma De . 259
20 Induction of Ocular Surface Regeneration
Irina S. Barequet 281
Section 6 Pancreas
Introduction
Shimon Efrat 298
21 Insulin-Producing Cells Generated from Nonpancreatic Tissues
Shimon Efrat 301
22 Generation of Islets from Pancreatic Progenitor Cells
Susan Bonner-Weir, Tandy Aye, Akari Inada,
Elena Toschi, and Arun Sharma . 309
23 Embryonic Stem Cells as a Source of Pancreatic Precursors
and Islet Cells In Vitro
Victoria L. Browning, Brenda W. Kahan, and Jon S. Odorico 321
Section 7 Hematology
Introduction
Arnon Nagler . 332
24 Human Umbilical Cord Blood Transplantation: A Viable Option
for Stem Cell Graft
Gal Goldstein, Amos Toren, and Arnon Nagler . 333
25 Nonmyeloablative Stem Cell Transplantation in the Treatment
of Hematologic Malignancies
Avichai Shimoni and Arnon Nagler . 351
26 Hematopoietic Stem Cell Transplantation from Human Leukocyte
Antigen Haploidentical Donor
Merav Leiba and Arnon Nagler 361
Section 8 Skin
Introduction
Nili Grossman . 372
27 Wound Healing and Skin Substitutes
Adam J. Singer and Marcia Simon 375
28 Skin Regeneration from Multipotent Adult and Embryonic Stem Cells
Kursad Turksen and Tammy-Claire Troy 395
Index 407
Color Insert . following page 206