他汀类还能降血压？

Use of statins and blood pressure.
他汀类药物可以降血压？
BACKGROUND: Markers of inflammation such as high-sensitivity C-reactive protein (CRP) were shown to be elevated in patients with hypertension. Small trials using statin therapy showed blood-pressure (BP) reductions, but it is unknown whether this association extends to larger populations. The objective of this study was to determine whether statin use was associated with better blood-pressure control in adults with hypertension and whether inflammation levels mediated this relationship.
背景：高灵敏性炎症指标CRP在高血压患者中升高。在小样实验中发现应用他汀类药物可以降低血压，但是它对大群体人的血压是否仍有作用目前还不知道。本研究的目的是研究他汀类药物是否能较好的控制成人的高血压，以及炎症水平是否在两者中有作用。
METHODS: This was a cross-sectional study of 2584 hypertensive adults aged >/=40 years with no known cardiovascular disease from the National Health and Nutrition Examination Survey 1999-2002. Logistic regression models were calculated to determine whether there was an association between statin use and blood-pressure control. C-reactive protein was added to the full model to determine its impact on the association.
方法：本研究是横向研究来自国家健康和营养检测中心的1999-2002年的2584名高血压患者，他们的年龄是大于等于40岁，而其是排除有心血管疾病。应用Logistic回归分析方法分析他汀类药物是否可以控制高血压。另外检测CRP的水平以研究其是与以上过程有相关性。
RESULTS: Compared with people not using statin medication, significantly more statin users had their blood pressure under control (52.2% v 38.0%). After adjustment for demographic factors, statin users were two times (95% confidence interval [CI], 1.46 to 2.72) more likely to have their blood pressure under control (<140/90 mm Hg) than nonusers. After further adjustment for body mass index, diabetes, smoking, exercise, low-salt diet, and antihypertensive medications, the likelihood of having blood pressure under control remained more likely among statin users (odds ratio, 1.46; 95% CI, 1.05 to 2.05). The association between statin use and lower BP was most evident among participants who used antihypertensive medication as well as statins and was unchanged with the addition of CRP to the model.
结果：与没有应用他汀类药物治疗的患者相比，使用者可以明显控制血压（52.2% 和38.0%）。在调定了人口因素后，应用他汀类药物后可以更有有效的控制血压，是没有应用的两倍。在进一步调定体重指数，糖尿病，吸烟，锻炼，低盐饮食和抗高血压药物后，应用他汀类药物同样可以控制血压。应用他汀类药物与降低血压之间的相关性在受试者中非常明显，但是CRP并没有明显的改变。
CONCLUSIONS: Statin use was associated with a BP level <140/90 mm Hg in a representative sample of US adults with hypertension. Levels of CRP did not attenuate the association. Further studies are needed to explore the effects of statin use on blood pressure and to determine how best to apply this knowledge in clinical care.
结论：应用他汀类药物可以使美国的那些成人高血压受试者中降低至140/90 mm Hg以下。CRP的水平并不能解释这种关系。还需要进一步的研究来探索他汀类药物对降低血压的效用，以及确定怎样更有效的将这一发现应用与临床。
初步翻译：他汀类药物可以降血压？
背景：高灵敏性炎症指标CRP在高血压患者中升高。在小样实验中发现应用他汀类药物可以降低血压，但是它对大群体人的血压是否仍有作用目前还不知道。本研究的目的是研究他汀类药物是否能较好的控制成人的高血压，以及炎症水平是否在两者中有作用。
方法：本研究是横向研究来自国家健康和营养检测中心的1999-2002年的2584名高血压患者，他们的年龄是大于等于40岁，而其是排除有心血管疾病。应用Logistic回归分析方法分析他汀类药物是否可以控制高血压。另外检测CRP的水平以研究其是与以上过程有相关性。结果：与没有应用他汀类药物治疗的患者相比，使用者可以明显控制血压（52.2% 和38.0%）。在调定了人口因素后，应用他汀类药物后可以更有有效的控制血压，是没有应用的两倍。在进一步调定体重指数，糖尿病，吸烟，锻炼，低盐饮食和抗高血压药物后，应用他汀类药物同样可以控制血压。应用他汀类药物与降低血压之间的相关性在受试者中非常明显，但是CRP并没有明显的改变。结论：应用他汀类药物可以使美国的那些成人高血压受试者中降低至140/90 mm Hg以下。CRP的水平并不能解释这种关系。还需要进一步的研究来探索他汀类药物对降低血压的效用，以及确定怎样更有效的将这一发现应用与临床。