Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis
一项 meta分析，50或50岁以上的人群，服用钙和钙与维生素D复合物补充剂，可防止骨折和骨质疏松
Summary摘要
Background背景
Whether calcium supplementation can reduce osteoporotic fractures is uncertain. We did a meta-analysis to include all the randomised trials in which calcium, or calcium in combination with vitamin D, was used to prevent fracture and osteoporotic bone loss.
该补充剂是否减少骨质疏松性骨折，还不十分肯定。进行一项meta分析，包括全部随意性试验，该试验，是服用钙和钙与维生素D复合物补充剂，防止骨折和骨质疏松
Methods
We identified 29 randomised trials (n=63 897) using electronic databases, supplemented by a hand-search of reference lists, review articles, and conference abstracts. All randomised trials that recruited people aged 50 years or older were eligible. The main outcomes were fractures of all types and percentage change of bone-mineral density from baseline. Data were pooled by use of a random-effect model.
方法
确定29项随意性试验(n=63 897)，用电子数据，补充一些研究资料的参考条目，评论文章，和会议摘要。所有随意性试验，招募的50岁获50岁以上的人群都是合格的。主要的结果，是各种类型的骨折和骨矿物质密度基线的百分比变化。资料是用随意的效果模式收集
Findings
In trials that reported fracture as an outcome (17 trials, n=52 625), treatment was associated with a 12% risk reduction in fractures of all types (risk ratio 0•88, 95% CI 0•83–0•95; p=0•0004). In trials that reported bone-mineral density as an outcome (23 trials, n=41 419), the treatment was associated with a reduced rate of bone loss of 0•54% (0•35–0•73; p<0•0001) at the hip and 1•19% (0•76–1•61%; p<0•0001) in the spine. The fracture risk reduction was significantly greater (24%) in trials in which the compliance rate was high (p<0•0001). The treatment effect was better with calcium doses of 1200 mg or more than with doses less than 1200 mg (0•80 vs 0•94; p=0•006), and with vitamin D doses of 800 IU or more than with doses less than 800 IU (0•84 vs 0•87; p=0•03).
调查结果
试验报告，骨折，（17项试验n=63 897）治疗效果，各种类型骨折的危险减少12% (risk ratio 0•88, 95% CI 0•83–0•95; p=0•0004).
试验报告，骨矿物质密度，治疗效果（23项试验n=41 419),臀部骨质疏松降低率0•54%(0•35–0•73; p<0•0001)和脊柱骨质疏松降低率1•19% (0•76–1•61%; p<0•0001)。
在顺从率高(p<0•0001)的试验中，骨折的危险减少明显大些(24%)
服用剂量的治疗效果比较，钙1200毫克或多于1200毫克比少于1200毫克的效果更佳(0•80 vs 0•94; p=0•006), 维生素D，800个国际单位或多于800个国际单位比少于800个国际单位效果更佳(0•84 vs 0•87; p=0•03).
Interpretation
Evidence supports the use of calcium, or calcium in combination with vitamin D supplementation, in the preventive treatment of osteoporosis in people aged 50 years or older. For best therapeutic effect, we recommend minimum doses of 1200 mg of calcium, and 800 IU of vitamin D (for combined calcium plus vitamin D supplementation).
解释说明
证据支持钙和钙与维生素D复合物补充剂，防止50岁或50岁以上的人群骨折和骨质疏松，推荐达到最佳效果的服用剂量，钙最低量为1200毫克，维生素D 800 IU国际单位（钙与维生素D复合物补充剂） |
发表于 2007-9-4 11:25:56