TNF-alpha Inhibitors (Milestones in Drug Therapy)

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TNF-alpha Inhibitors (Milestones in Drug Therapy)
Product Details
Book Publisher: Birkh鋟ser Basel (30 June, 2006)
ISBN: 3764372486
Book author: Jeffrey M. Weinberg, Robin Buchholz
Book Description:
Over the last decade, the advent of biologicagents has greatly revolutionized therapeutic medicine in themanagement of chronic inflammatory diseases, such as rheumatoidarthritis, Crohn’s disease,and psoriasis. Elucidation of the complex web of cytokine network andthe roles of these cytokines in the pathogenesis of inflammatorydisorders provided one of the key catalysts for the advancement oftargeted biologic therapy in autoimmune and inflammatory diseases.
TNF-alphais known to play a crucial role in the pathogenesis of many chronicinflammatory diseases. Elevated levels of TNF-alpha have beendemonstrated in Crohn’s disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis,suggesting a role for TNF-alpha in their pathogenesis. AlthoughTNF-alpha plays a critical role in the activation of innate andacquired immune responses, the persistence of the immune response andinappropriate production of TNF-alpha can produce pathological changesresulting from chronic inflammation and tissue damage.
This volumeprovides a comprehensive overview of the development, pharmacology,efficacy, and safety of the currently available TNF-alpha inhibitors –etanercept, infliximab, and adalimumab. The most recent preclinical andclinical data is presented on this topic, which should be of interestto the preclinical researcher, the clinician, and the patient who wantsto learn more about these therapies.

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