Scientific Foundations of Clinical Practice: Part II, An Issue of Pediatric C

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By Ellis Avner, Robert M. Kliegman,

Publisher:  Saunders
Number Of Pages:  240
Publication Date:  2006-10-27
Sales Rank:  3808669
ISBN / ASIN:  1416038973
EAN:  9781416038979
Binding:  Hardcover
Manufacturer:  Saunders
Studio:  Saunders


In the last decade, the delineation of the human genome and the development of high throughput genomics and proteomics have transformed the practice of Pediatrics. The study of normal childhood growth and development, and pediatric diseases now focuses on the delineation of normal and abnormal gene expression, resultant cellular and organ responses, and the modification of such interactions by an increasing number of environmental factors. This is the second of two issues of the Pediatric Clinics of North America will provide an overview of the rapidly developing field of Pediatric Translational Medicine. New knowledge of basic molecular and  developmental physiology and pathophysiology is rapidly being \"translated\" into new diagnostics and therapeutics for the practicing pediatrician. Rapid molecular diagnostics based on the identification of new disease genes, recognition of unique disease phenotypes at the cellular level, and the development of new therapeutic approaches based on pharmacogenomic profiling suggest that \"individualized medicine\" will soon be a possibility for every child. Combined with similar advances in epidemiology, bioinformatics, and population-based studies, Pediatric Translational Medicine will rapidly move from the laboratory bench to the patient bedside. These issues of the PCNA will be of value to all members of the pediatric health care delivery team, which now includes basic and clinical investigators. Further, it will provide students at all levels with a sense of the excitement which awaits their future development as tomorrow's Physician-Scientists.



Preface
Functional Genomics and Its Implications for Molecular Medicine
Current Methods for the Rapid Diagnosis of Bioterrorism-Related Infectious Agents
Human Artificial Chromosomes: Potential Applications and Clinical Considerations
Inborn Errors of Development: Disruption of Pathways Critical for Normal Development
Transcriptional Regulation of Perinatal Lung Maturation
Renal Cystic Disease: New Insights for the Clinician
Defects in Surfactant Synthesis: Clinical Implications
The Cell Biology of Acute Childhood Respiratory Disease: Therapeutic Implications
Pulmonary Hypertension in Children: The Twenty-First Century
Molecular and Cellular Basis of Congenital Heart Disease
The Molecular Basis of Pediatric Hypertension
Reactive Oxygen Species Cerebral Autoregulation in Health and Disease


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