Trinucleotide Repeat Protocols (Methods in Molecular Biology)

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Trinucleotide Repeat Protocols (Methods in Molecular Biology)
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Publisher:  Humana Press
Number Of Pages:  360
Publication Date:  2004-06-18
Sales Rank:  3007835
ISBN / ASIN:  1588292436
EAN:  9781588292438
Binding:  Hardcover
Manufacturer:  Humana Press
Studio:  Humana Press
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Book Description:

Established leaders in trinucleotide repeat disease describe in step-by-step detail their best techniques for studying trinucleotide pathology at the molecular level. The protocols cover a variety of targets, ranging from DNA and RNA to proteins and whole animals, and focus not only on causal genes, but also on their consequent affected products, such as transcription factors, neurotransmitter receptors, proteasomes, and mitochondria/oxidation damage. Experimental systems employed include E. coli, yeast, C. elegans, mouse, and generally take a clinical point of view. The authors utilize a wide range of techniques, including gel electrophoresis, quantitative RT-PCR, immunological analysis, antibody usage and its applications, receptor assays using radioisotope handling, gene delivery by virus, brain cell and organotypic cultures, gender dependency, and neuron structure analysis.

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