skychen 发表于 2008-4-18 08:33:26

丹参酮_A诱导急性早幼粒细胞性白血病分化机制的研究

Objective In order to study the differentiation molecular mechanism of acute promyelocytic leukemia (APL) cells induced by TanⅡA in vitro, and to provide application rationales of TanⅡA to APL patient treatment, the differentiation expression in aspects of cell biology and molecular biology induced by TanⅡA were compared with that induced by all-trans retinoid acid (ATRA) and arsenic trioxide (As_2O_3). 2 Materials and methods 2.1 Cell culture Logarithmically growing NB_4 cell were c...


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