IL-6：卫星细胞介导的骨骼肌肥大的必要调控因子
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle HypertrophySkeletal muscles adapt to increasing workload by augmenting their fiber size, through mechanisms that are poorly understood.
This study identifies the cytokine interleukin-6 (IL-6) as an essential regulator of satellite cell (muscle stem cell)-mediated hypertrophic muscle growth. IL-6 is locally and transiently produced by growing myofibers and associated satellite cells, and genetic loss of IL-6 blunted muscle hypertrophy in vivo. IL-6 deficiency abrogated satellite cell proliferation and myonuclear accretion in the preexisting myofiber by impairing STAT3 activation and expression of its target gene cyclin D1. The growth defect was indeed muscle cell intrinsic, since IL-6 loss also affected satellite cell behavior in vitro, in a STAT3-dependent manner. Myotube-produced IL-6 further stimulated cell proliferation in a paracrine fashion.
These findings unveil a role for IL-6 in hypertrophic muscle growth and provide mechanistic evidence for the contribution of satellite cells to this process.
http://www.cellmetabolism.org/content/article/abstract?uid=PIIS155041310700366X
作者单位
1 Program on Differentiation and Cancer, Center for Genomic Regulation (CRG) and Center for Neurodegenerative Diseases (CIBERNED), Pompeu Fabra University, E-08003 Barcelona, Spain
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