体重指数与哮喘严重程度的关系
Body mass index and asthma severity in the National Asthma SurveyB Taylor1, D Mannino2, C Brown3, D Crocker3, N Twum-Baah1, F Holguin1
Background: The association between obesity and asthma severity remains controversial and limited to small studies.
Methods: We determined the association of body mass index (BMI) and asthma severity in the National Asthma Survey. We included adults (age 18 years) who self-reported symptoms of asthma in the past 5 years. A total of 3095 patients were divided into the following BMI categories: 1080 (35%) non-overweight (BMI <25), 993 (32%) overweight (BMI 25 and <30) and 1022 (33%) obese (BMI 30). Asthma severity measures included respiratory symptoms, healthcare utilisation, medication use, missed work days and the Global Initiative for Asthma (GINA) severity classification. Models were adjusted for: gender, race, age, education, income, employment status, smoking status, family history of asthma, state of residence and residence in a metropolitan statistical area.
Results: Compared with non-overweight subjects, obese subjects with asthma were more likely to report continuous symptoms (OR 1.66, 95% CI 1.09 to 2.54), miss more work days (OR 1.35, 95% CI 1.01 to 1.81), use short acting beta agonists (OR 1.36, 95% CI 1.06 to 1.75), use inhaled corticosteroids (OR 1.34, 95% CI 1.01 to 1.79) and use any controller medication according to GINA guidelines (OR 1.37, 95% CI 1.01 to 1.85). Also, obese respondents were less likely to be in asthma remission (OR 0.56, 95% CI 0.38 to 0.82) and were more likely to have severe persistent asthma (GINA IV) (OR 1.42, 95% CI 1.05 to 1.90).
Conclusions: In a large, diverse sample of adults with asthma, obesity was associated with measures of asthma severity after adjusting for potential confounders.
背景：肥胖和哮喘严重程度之间的相关性一直存在争议，且相关研究的规模都较小。
结论：在大规模、有代表性的成人哮喘样本中，调整了潜在的混杂因素后，肥胖与哮喘的严重程度具有相关性。
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